还原型谷胱甘肽对急性冠脉综合征患者血浆C-反应蛋白的影响

目的探讨应用还原型谷胱甘肽(GSH)对急性冠脉综合征(ACS)患者血浆C-反应蛋白(CRP)的影响。方法经临床诊断ACS38例,随机分为治疗组和对照组,各19例。对照组给予ACS一般治疗;治疗组除给予ACS一般治疗外,加用GSH1.2g/d,共7d。用免疫比浊法检测2组血清CRP。结果2组治疗前和对照组治疗前后的血浆CRP比较差异无统计学意义;治疗组CRP治疗后较治疗前下降37.26%,差异有统计学意义(P<0.05)。结论应用还原型谷胱甘肽治疗ACS患者能够使CRP显著下降,提示GSH有抗炎作用。

Effects of reduced glutathione on serum levels of C-reactive protein in patients with acute coronary syndrome

Objective To observe the effects of reduced glutathione on serum levels of C-reactive protein(CRP) in patients with acute coronary syndrome(ACS). Methods Thirty-six patients who had been diagnosed with ACS were randomized into two groups: group treated with routine therapy (control group)(n=18) and group treated with reduced glutathione(treatment group)(n=18),control group just only accepted routine therapy of ACS; treatment group accepted reduced glutathione 1.2 g per day for 7 days after admission, in addition with routine therapy of ACS. Plasma CRP of two groups patiens measured by ITM. Results There were no statistical difference for the concerntration of plasma CRP between two groups before medical intervention.So does in Control group before and after treatment.The concerntration of plasma CRP reduced 37.26% in treatment group and the change had a significant statistics with P<0.05. Conclusion With treatment with reduced glutathione in ACS patiens after admission,the concerntration of plasma CRP decreased remarkably.This study demonstrated that reduced glutathione could have effects of anti-inflammation.