Antispermatogenic activity of 1-p-chlorobenzyl-1H-indazol-3-carboxylic acid (AF 1312/TS) in rats. I. Trials of single and short-term administrations with study of pharmacologic and toxicologic effects.

A new antispermtogenic agent is described. Following single or short-term administrations, 1-p-chlorobenzyl-1H-indazol-3-carboxylic acid, or $\text{AF 1312}\text{TS}$, produced in rats a long-lasting inhibition of the spermatogenic process. In adult rats the secondary sex organs were not affected, while in young rats some weight decrease of the prostate, seminal vesicles and levator ani was observed. The interstitial tissue of the testes as well as thymus, adrenals and hypophysis were not affected. $\text{AF 1312}\text{TS}$ proved to be devoid of the most common pharmacological activities.