山西地区91株淋球菌耐药性分析

目的检测山西地区淋病奈瑟菌（NG）对5种抗生素的敏感性，分析其耐药特点。方法K—B琼脂扩散法测定NG对抗生素的敏感性及产色头孢噻吩法检测β-内酰胺酶。结果91株淋球菌对青霉素、四环素、环丙沙星、头孢曲松和大观霉素的耐药率分别为69．23％、87．91％、97．80％、0和5．49％，检出质粒介导的产青霉素酶的淋病奈瑟菌（PPNG）38株（41．76％），同时耐2种及2种以上抗菌药物的多重耐药率为94．51％。结论青霉素、四环素及环丙沙星已不宜用于山西地区淋病的治疗；头孢曲松和大观霉素耐药率较低，可以作为山西地区治疗淋病的首选药物。但是大观霉素已出现耐药株．应引起重视。同时山西地区多重耐药现象十分严重。持续监测淋球菌的耐药性十分必要。

Resistance analysis of 91 strains of Neisseria gonorrhoeae in Shanxi

Objective To survey the antibiotic susceptibility and resistance trends of Neisseria gonorrhoeae to 5 Antibiotics in Shanxi. Methods The susceptibility to 5 antibiotic angents was tested by the disk diffusion method and β-lactamase determined by nitrocefin. Results The resistance rates of 91 strains to penicillin, tetracycline, ciprofloxacin, cefiriaxone, spectinomyein were 69.23%, 87,91%, 97.80%, 0, 5.49% ,penicillinase-produeing neisseria gonorrhoeae （PPNG） accounted for 41.76%, resistance rates of multiple-resistance isolates to 5 antibiotics were 94.51%. Conclusion Penicillin, tetracycline, ciprofloxacin cannot be used as routine agents to treat gonorrhea, ceftriaxone and spectinomycin should be used as the first line agents in treating gonorrhea at present in shanxi area. However attention should be paid to the appearance of some resistance strains to spectinomycin.Meanwhile,multi-drugs resistance in Neisseria gonorrhoeae exists widespreadly.It is of great importance to continuously survey the susceptibilities of NG to antibiotic.