北京地区3050例健康体检者高敏C反应蛋白水平与代谢综合征及其组分的相关性研究

目的调查北京地区脑力工作者的代谢综合征（MS）发病率和hs-CRP水平变化情况,探讨hs-CRP在MS患者中的分布特点及其相互关系。方法对2008年3月-2009年3月在我院接受健康体检的3050例（男2345例,女705例）从事管理、科研的脑力工作者进行体重指数（BMI）、腰围（WC）、血压、高敏C反应蛋白（hs-CRP）、空腹血糖（FPG）、糖耐量2h血糖（2hPG）、总胆固醇（TC）、甘油三脂（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）调查和检测。MS诊断采用国际糖尿病联盟（IDF）标准。结果3050例调查人群中有942例（31.00%）MS患者,男707例（30%）,女235例（33.3%）。对应于具有MS组分0、1、2、≥3个的人群,其中男性hs-CRP水平中位数为1.22mg/L、1.47mg/L、1.94mg/L、2.50mg/L,女0.84mg/L、1.03mg/L、1.56mg/L、2.87mg/L,CRP水平随MS组分的增加明显升高（P〈0.001）。Stepwise逐步回归分析显示,男性hs-CRP水平的独立影响因素为BMI、HDL-C、年龄、TC、LDL-C、2hPG（R=01351，R^2=0．123，P〈0．05）；女性hs—CRP水平的独立影响因素为BMI、TG、年龄、FBG、TC、HDL—C（R=0．525，R^2=0．276，P〈0．05）。结论北京地区的脑力工作者MS患病率明显高于我国平均水平。随MS异常组分数的增加。hs—CRP水平明显升高，提示hs—CRP是MS发病机制的一部分，是MS发生、发展的一个危险因素，而控制体重、有效干预糖、脂代谢紊乱是降低hs—CRP的重要措施。

Association between high-sensitive C-reactive protein level and metabolic syndrome and components thereof in 3050 brain workers in Beijing

Objective The aim of this study was to explore the prevalence of metabolic yndrome（MS） and the level of high-sensitive C-reactive protein （hs-CRP）, and study the Association between hs-CRP level and MS and components thereof among brain workers in Beijing. Methods A cross-sectional survey was conducted among 3 050 brain workers （men 2 345, women 705） while physical examination was undergoing in our hospital from March 2008 to March 2009 in Beijing. The BMI, WC, blood pressure, hs-CRP, fasting blood glucose（FPG）,2 hours blood glucose（2hPG）, total cholesterol（TC）,triglyceride （TG）, high density lipoprotein cholesterol （HDL-C）, low density lipoprotein cholesterol （LDL-C） were investigated and determined. The MS was diagnosed according to the International diabetes federation （IDF）. Results The prevalence of MS were 31.0%（men 30.0%,women 33.3%）in 3 050 brain workers. Median CRP levels for men with 0,1,2,≥3 components of the MS were 1.22,1.47,1.94 and 2.50mg/L, for women were 0.84, 1.03, 1.56 and 2.87 mg/L, respectively. The hs-CRP level was increased with the components of MS （P〈0.001）. Stepwise analysis showed that the BMI,HDL-C,age,TC,LDL-C,2hPG were independent predictors of hs-CRP for men （R=0.351 ,R^2=0.123,P〈0.05）, the BMI,TG,age,FBG,TC,HDL-C were independent predictors of hs-CRP for women （R=0.525, R^2=0.276,P〈0.05 ）, respectively. Conehltsion Compared with the national average level, the prevalence of MS was significantly high among brain workers in Beijing. The hs-CRP level was increased with the components of MS, which suggested that the high hs-CRP level was a risk factor for the MS occurring and developing. The prevention and control of overweight/obesity and blood glucose and lipids disorder were the most important steps for decreasing the level of hs-CRP.