中药通心络对冠心病患者同型半胱氨酸和不对称二甲基精氨酸的影响

目的：探讨中药通心络对冠心病患者同型半胱氨酸（H刚和不对称二甲基精氨酸（ADMA）的影响，为冠心病的治疗提供新的依据。方法：冠心病患者100例，随机分为中药组（A组）和西药组（B组）各50例。A组给予通心络（由人参、水蛭、全蝎、土鳖虫、蜈蚣、蝉蜕等组成）治疗，B组给予叶酸、维生素B6、B12治疗。健康体检者20例为正常组。测定其血清ADMA、Hcy，统计硝酸酯类药停减率，进行动态心电图和临床疗效观察。结果：3个月后，两组的Hcy水平降低，治疗前后比较均有显著性差异（P〈0．05），而ADMA无显著变化（P〉0．05）；A组的硝酸酯类药停减率明显较B组高（89．3％vs．26．7％。P〈0．01）；A组ST-T改善情况优于B组（P〈0．05）；A组显效17例、有效23，总有效率80％，B组显效7例、有效20例，总有效率54％，两组比较，差异有显著性意义（P〈0．05）。结论：中药通心络能够改善冠心病患者的高同型半胱氨酸血症，而对ADMA则无显著影响，在改善动态心电图和临床症状等方面中药疗效优于西药的叶酸、维生素B6、B12.

Effects of Chinese Traditional Medicine on Blood Homocysteine and Asymmetric Dimethylarginine of the Patients with Coronary Heart Disease

Objective： To observe the Effects of Chinese traditional medicine on homocysteine （Hey） and asymmetric dimethylarginine （ADMA） of the patients with coronary heart disease. Methods： 100 patients with coronary heart disease were divide into two groups, the A group were given Chinese traditional treatment（include Panax, leech, scorpion, etc）, the B group were given folic acid＋ VB6＋ VB12. 20 healthy subjects were as normo-group. The ADMA, Hcy of blood serum were measured, statistic the stopped rate of nitrates, and observe dynamic electrocardiogram and the clinical effect. Results： After six months, the Hey of the two groups decreased significantly （P〈0.05）, and ADMA were not significantly different （P〉0.05） compared with those before supplement. The stopped by nitrates drug in A group was significantly higher than that in group B （89.3% vs. 26.7%, P〈0.01）. ST-T show A group＇s situation is better than group B. A group of 17 cases obvious, effective 23, the total efficiency is 80%, Group B 7 cases obvious, 20 cases effectively, the total efficiency is 54%, the difference of the two groups was significant （P〈0.05）. Conclusion： Chinese medicine may improve hyper homocysteine, but have no effects on levels of ADMA of the patients with coronary heart disease. But Chinese medicine is superior in improving DCG and the clinical symptoms than Western medicine of folic acid, vitamin B6 and B12.