妊娠早期子痫前期的预测

子痫前期是发病率和病死率较高的产科并发症,以滋养细胞浅侵入母体子宫螺旋动脉为特征.尽管对子痫前期的病理生理改变已有较多的了解,但有效及时的预测是非常困难的.虽然不同检测方法均认为胎盘功能不良与妊娠不良结局有关,但用单一指标做预测的效果很差.超声技术的提高对预测十分有利,但需要标准化.妊娠早期母亲生化标记物结合子宫动脉多普勒筛查可能是很有前途的筛查工具.

Prediction of Preeclampsia in the First Trimester

Preeclampsia is a obstetrical complication with high perinatal mortality and morbidity. It is characterized by shallow trophoblast invasion in maternal uterine spiral arteries. Despite there are more and more understanding on the pathophysiology of preeclampsia,it is difficult to predict effectively in time in clinic. There are some relationship between the disordered placenta function and the poor pregnancy outcomes. However, any single parameter of placenta function could not be used as a exact predictor for preeclampsia. The improved ultrasound will provide a useful novel tool for prediction,but measurement of ultrasound need to be standardized. The test of biochemical markers in the first trimester, combined with the uterine artery Doppler screening, may be a promising screening tool.