| 氨基酸作为葡萄球菌的镇咳成分 |
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| 引用本文： | 夏贤汉,刘裕云,周茉华,吴静娴,赵刚,李波. 氨基酸作为葡萄球菌的镇咳成分[J]. 中国新药与临床杂志, 1988, 0(6) |
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| 作者姓名： | 夏贤汉 刘裕云 周茉华 吴静娴 赵刚 李波 |
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| 作者单位： | 卫生部武汉生物制品研究所 武汉430060(夏贤汉，刘裕云)，湖北中医学院 武汉430060(周茉华，吴静娴，赵刚)，湖北中医学院 武汉430060(李波) |
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| 摘 要： | 本研究发现了表皮葡萄球菌(Staphyloco-ccus epidermidis)的镇咳有效成份是氨基酸,并通过对各种常见氨基酸的镇咳试验,进一步发现苯丙氨酸、苏氨酸、亮氨酸和异亮氨酸有明显的镇咳作用和它们之间的协同功能。这不仅对控制和提高其产品“白葡菌止咳片”的质量有较大的实用价值;而且还揭开了上述氨基酸的新功能或新用途,为进一步开发新产品展示了前景。
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| 关 键 词： | 表皮葡萄球菌 氨基酸类 镇咳剂 |
Amino acids as the antitussive components of Staphylococcus epidermidis |
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| XIA Xian-Han,LIU Yu-Yun. Amino acids as the antitussive components of Staphylococcus epidermidis[J]. Chinese Journal of New Drugs and Clinical Remedies, 1988, 0(6) |
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| Authors: | XIA Xian-Han LIU Yu-Yun |
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| Abstract: | The antitussive efficacy of Staphyiococcus epidermidis has been reported on cough patients(1). In this study, the suspension of Staphyiococcus epidermidis was repeatedly frozen and thawed. The filtrate was dialysed against water. The dialysate was evaporated to dryness and white crystals were obtained.The dialysate and crystals were given to mice by intragastric gavage. After 1h, the mice were exposed to ammonia inhalation. The antitussive components were found to be amino acids,among which Phe, Thr, Leu and He were most potent and syner-gistic. |
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| Keywords: | Staphyloccccus epidermidis amino acids antitussive agents |
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