Factors determining the maintenance dose of warfarin in Chinese patients |
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Authors: | Yu, HC Chan, TY Critchley, JA Woo, KS |
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Affiliation: | Department of Medicine, Chinese University of Hong Kong. |
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Abstract: | Chinese patients are reportedly more sensitive than Caucasians to theanticoagulant effect of warfarin. We examined warfarin dose requirementsand their determinants in 151 Chinese out-patients on stable maintenancedose of warfarin with international normalized ratio of 2 to 2.5. Meandaily warfarin requirement was 3.3 +/- 1.4 mg, much lower than reporteddoses in Caucasian patients. The most important determinant was age (r =-0.43, p < 0.001), with progressively lower warfarin requirement withincreasing age (p = 0.0001). There was a weaker association with bodyweight (r = 0.20, p = 0.01). Patients with chronic rheumatic heart diseasetended to require a smaller dose than those with heart valve replacements(2.94 +/- 1.24 vs. 3.69 +/- 1.42 mg, p < 0.01). We confirm that Chinesepatients require a smaller dose of warfarin for the same degree ofanticoagulation. Age is the most important factor affecting doserequirement, although body weight and underlying disease also play a role. |
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