Factors determining the maintenance dose of warfarin in Chinese patients |
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Authors: | Yu HC; Chan TY; Critchley JA; Woo KS |
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Institution: | Department of Medicine, Chinese University of Hong Kong. |
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Abstract: | Chinese patients are reportedly more sensitive than Caucasians to the
anticoagulant effect of warfarin. We examined warfarin dose requirements
and their determinants in 151 Chinese out-patients on stable maintenance
dose of warfarin with international normalized ratio of 2 to 2.5. Mean
daily warfarin requirement was 3.3 +/- 1.4 mg, much lower than reported
doses in Caucasian patients. The most important determinant was age (r =
-0.43, p < 0.001), with progressively lower warfarin requirement with
increasing age (p = 0.0001). There was a weaker association with body
weight (r = 0.20, p = 0.01). Patients with chronic rheumatic heart disease
tended to require a smaller dose than those with heart valve replacements
(2.94 +/- 1.24 vs. 3.69 +/- 1.42 mg, p < 0.01). We confirm that Chinese
patients require a smaller dose of warfarin for the same degree of
anticoagulation. Age is the most important factor affecting dose
requirement, although body weight and underlying disease also play a role.
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