| WAF1／CIP1mRNA在银屑病表皮中的表达 |
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| 引用本文： | 刘振祥 张波. WAF1／CIP1mRNA在银屑病表皮中的表达[J]. 临床皮肤科杂志, 1998, 27(6): 359-360 |
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| 作者姓名： | 刘振祥 张波 |
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| 作者单位： | [1]北京医科大学第三医院皮肤科 [2]北京医科大学基础医学院 |
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| 摘 要： | 采用原位杂交法研究了ＷＡＦ１／ＧＩＰ１ｍＲＮＡ在正常表皮及银屑病患者表皮中的表达。发现ＷＡＦ１／ＣＩＰ１ｍＲＮＡ在４便正常对照皮肤中不表达，在２８例银屑病患者表皮中呈高表达，ＷＡＡＦ１／ＣＩＰ１ｍＲＮＡ主要在银屑病患者表皮棘细胞层上部和颗粒层细胞中表达，在基底细胞层则基本表达。提示ＷＡＦ１／ＣＩＰ１ｍＲＮＡ在银屑病患者表皮中的高表达可能与银屑病表皮的细胞分化有关。
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| 关 键 词： | 银屑病 WAF1／CIP1 mRNA 表皮 |
Expression of WAF_1 /CIP_1 mRNA in psoriatic epidermis |
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| Liu Zhenxiang, Li Shiyin, Zhang Bo, Kou Jiehong.. Expression of WAF_1 /CIP_1 mRNA in psoriatic epidermis[J]. Journal of Clinical Dermatology, 1998, 27(6): 359-360 |
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| Authors: | Liu Zhenxiang Li Shiyin Zhang Bo Kou Jiehong. |
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| Abstract: | The expression of WAF1/CIP1 mRNA in normal skin and psoriatic epidermis was studied with in situ hybridization. No expression of WAF1 /CIP1 mRNA in normal skin of 4 individuals, and overexpression of WAF/CIP1 mRNA in lesional psoriatic epidermis of 28 cases were observed. WAF1 /CIP1 mRNA was elevated in the cells of the suprabasal layers of lesional psoriatic epidermis, with little or no detectable expression in the basal layer. These results suggest that overexpression of WAF1 /CIP1 mRNA in lesional psoriatic epidermis may involve the control of cell differentiation of psoriatic epidermis. |
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| Keywords: | Psoriasis WAF_1/CIP_1 |
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