三维超声结合母血清生化指标在中孕期胎儿筛查中的价值

目的 探讨三维超声结合母血清生化指标在中孕期胎儿筛查中的价值.方法　对中孕期胎儿分系统进行三维超声检查,再结合母血清中甲胎蛋白(AFP)、人绒毛膜促性腺激素β亚基(Free-βHCG),诊断胎儿畸形情况,并与引产或出生后的胎儿对照分析.结果 1108例中孕期胎儿三维超声检查结构异常15例,漏诊5例,误诊2例.1108例母血清生化指标检查,唐氏综合征高风险123例,18例行羊水检查,其中唐氏综合征高风险6例.1108例中神经管畸形高风险者49例.两种检查方法比较,有统计学意义.结论　该方法有效地减少胎儿畸形的漏诊和误诊,提高患者的满意率,最大限度地减少医疗纠纷,减低医疗风险,减轻医生的压力.

The clinical value of 3-D ultrasound combined serum biochemical indexes in the fetal screening in the midtrimester

Objective To explore the clinical value of 3-D ultrasound combined serum biochemical indexes in the fetal screening in the midtrimester.Methods The fetal screening was conducted by combination 3-D ultrasound and serum alpha fetoprotein(AFP) and betasubunit of human chorionic gonadotropin(β-hCG) levels.The above data were analyzed among the fetal and infant.Results There were 15 abnormal construction,5 missed diagnosis,2 misdiagnosis in 1 108 cases of 3-Dultrasound detection in midtrimester.Biochemical indexes indicated that there were 123 high risk of Down’s syndrome.Amniocentesis showed 18 high risk of Down’s syndrome,and 49 high risk of neural tube defects.The results were considered to be statistical significance.Conclusion The combination of 3-D ultrasound and biochemical indexes in the midtrimester revealed that the missed and misdiagnosis can be reduced,will further enhance the efficiency of fetal screening.