Interaction between 16α,17α-cyclopropane progesterone and progesterone receptors in rat uterus |
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Authors: | A N Smirnov E V Pokrovskaya V P Shevchenko I S Levina A V Kamernitskii |
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Institution: | (1) Laboratory of Endocrinology, Biological Faculty of M. V. Lomonosov State University, Moscow;(2) Laboratory of Radiolabeled Bioactive Substances, Institute of Molecular Genetics, Russian Academy of Sciences, Moscow;(3) Group of Steroid and Hydroxylipine Chemistry, N. D. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, Moscow |
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Abstract: | Binding of3H-16α, 17α-cyclopropanoprogesterone (CPG) and3H-progesterone (PG) to progesterone receptors in soluble fraction of rat uterus is studied. It is shown that CPG and PG specifically
bind to the protein with similar affinity and binding capacity. Unlabeled PG competitively inhibits the binding of CPG, and
unlabeled CPG competitively inhibits the binding of PF with the same efficiency. Dissociation of CPG- and PG-receptor complexes
is characterized by the same dissociation constant.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 5, pp. 532–534, May, 1998 |
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Keywords: | Progesterone progesterone receptor progesterone analog steroid-receptor interaction |
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