葡萄糖酸锌治疗儿童急性腹泻的临床观察

目的 探讨急性腹泻患儿血锌变化,并观察口服葡萄糖酸锌治疗儿童急性腹泻的临床疗效及意义。方法对186例急性腹泻伴中、重度脱水患儿进行血锌检测,并与正常儿童进行对照。将186例患儿随机分为两组,治疗组95例,对照组91例,两组患儿均采用综合治疗（补充水、电解质、纠正酸中毒、微生态治疗等）,治疗组在综合治疗的基础上口服葡萄糖酸锌,剂量〈6个月,口服70mg／d（相当于元素锌10mg／d）,〉6个月,口服140me／a（相当于元素锌20mg／d）,分3次口服．14．14d为1疗程。结果急性腹泻患儿血锌值为（86．95±16．29）mg／L,正常对照患儿血锌值为（106．48±10．98）mg／L,两组比较：t=8．07,P〈0．01,差异有统计学意义。治疗组显效70例（73．7％）,有效19例（20％）,总有效率93．7％,对照组有显效55例（60．4％）,有效18例（19.8％）,总有效率80．2％,两组比较：x^2=7．49,P〈0．01。结论急性腹泻患儿存在锌的缺乏,合理补充微量元素锌有助于急性腹泻病的防治。

Clinical observation of zinc gluconate's effect on acute, diarrhea of children

Objective To investigate serum zinc level in children with acute diarrhea and the therapy effect of zinc gluconate on children with acute diarrhea. Methods Serum zinc level from 186 children with mederate or serious dehydration were tested and contrasted with that in normal children,then these children were randomly assigned to two group：therapy group, and contrast group. These two group all treated with combined therapy, and therapy group still given zinc gluconate to take for 10 or 14 days. dose：Age 〈 6 month： 70mg/d （element zinc 10mg/d）, age 〉 6 month 140mg/d（element zinc 20mg/d）. Results Serum zinc level in children with acute diarrhea was（86.95 ± 16.29）mg/d,but was （ 106.48 ± 10.8） mg/d in normal children, which showed significant difference（ t = 8.07, P 〈 0.01 ） ; in therapy group： significant effect was 70 （73.7 % ）, effect was 19 （ 20% ）, the total effect rate was 93.7 % ; in contast group： the significant effect was 55 （60.4 % ）, effect was 18 （ 19.8 % ）, the total effect rate was 80.2 %, which showed statistical difference （ X^2 = 7.49, P 〈 0.01 ）. Conclusion Element zinc was deficiency in children with acute diarrhea, and reasonable supplemont element zinc will helpful to the prevention and cure of acute diarrhea.