| 新型血小板聚集功能缺陷症患者血小板5-HT及其释放反应的研究 |
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| 引用本文： | 王前,沈迪,王爱莲.新型血小板聚集功能缺陷症患者血小板5-HT及其释放反应的研究[J].华中科技大学学报(医学版),1990(6). |
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| 作者姓名： | 王前 沈迪 王爱莲 |
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| 作者单位： | 同济医科大学血液病研究所
(王前，沈迪)，同济医科大学血液病研究所(王爱莲) |
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| 摘 要： | 用荧光分光光度法测得14例新型血小板聚集功能缺陷症患者血小板5-羟色胺(5-HT)浓度,以及用ADP诱导患者血小板后测其5-HT释放率,分别与正常对照组比较,差异均无显著意义。用刺参酸性粘多糖(SJAMP)作用于血小板,正常对照组和患者组血小板5-HT释放率分别为63.2±3.2％和21.2±5.3％(x±s),差异有显著意义(P<0.01)。患者血小板经洗涤后用SJAMP激活,其5-HT释放率有所恢复(P<0.05)。结果表明,本病患者血小板5-HT贮存无异常,但存在释放缺陷,可能有某种血浆因子干扰SJAMP与血小板膜受体结合。
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| 关 键 词： | 新型血小板聚集功能缺陷症 5-羟色胺(5-HT) 荧光光谱测定法 |
Studies on Platelet 5-hydroxytryptamine Level and Its Release Reaction in Patients with a New Variant of Platelet Aggregation Defect |
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| Wang Qian,Shen Di,Wang Ailian Institute of Haematology,Tongji Medical University,Wuhan.Studies on Platelet 5-hydroxytryptamine Level and Its Release Reaction in Patients with a New Variant of Platelet Aggregation Defect[J].Journal of Huazhong University of Science and Technology(Health Sciences),1990(6). |
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| Authors: | Wang Qian Shen Di Wang Ailian Institute of Haematology Tongji Medical University Wuhan |
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| Abstract: | |
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| Keywords: | a new variant of platelet aggregation defect platelet 5-hydroxy-tryptamine fluorescence spectrophotometry |
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