| 丹皮酚抗鹌鹑实验性动脉粥样硬化作用 |
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| 引用本文： | 戴敏,訾晓梅,彭代银,刘青云.丹皮酚抗鹌鹑实验性动脉粥样硬化作用[J].中国中药杂志,1999,24(8):488-490. |
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| 作者姓名： | 戴敏 訾晓梅 彭代银 刘青云 |
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| 作者单位： | 安徽中医学院 合肥 230038 |
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| 摘 要： | 目的：研究丹皮酚对鹌鹑实验性动脉粥样硬化的抑制作用。方法：观察丹皮酚灌胃给药（６００，３００ｍｇ·ｋｇ－１）后在鹌鹑实验性动脉粥样硬化形成中调节血脂、改善血液流变学、减轻主动脉脂质斑块形成的作用。结果：口饲丹皮酚可明显降低实验动物血清ＴＣ，ＴＧ，ＬＤＬ，ｖＬＤＬ，ａｐｏＢ100含量，提高ＨＤＬ含量及ＨＤＬ／ＴＣ，ＨＤＬ２／ＨＤＬ3，ａｐｏＡ1／ａｐｏＢ100比值；不同程度地降低低切变率下全血比粘度、血浆比粘度、纤维蛋白原比粘度、红细胞聚集性。显著减少主动脉壁及肝脏ＴＣ含量，缩小斑块面积，抑制主动脉脂质斑块形成。结论：口饲丹皮酚具有抗鹌鹑实验性动脉粥样硬化作用。
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| 关 键 词： | 丹皮酚 动脉粥样硬化 脂质 血液流变学 |
| 收稿时间： | 1998/4/13 0:00:00 |
Inhibitory Effect of Paeonol on Experimental Atherosclerosis in Quails |
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| Dai Min;Zhi Xiaomei;Peng Daiyin ; Liu Qingyun.Inhibitory Effect of Paeonol on Experimental Atherosclerosis in Quails[J].China Journal of Chinese Materia Medica,1999,24(8):488-490. |
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| Authors: | Dai Min;Zhi Xiaomei;Peng Daiyin ; Liu Qingyun |
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| Institution: | Anhui College of Traditional Chinese Medicine, Hefei 230038. |
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| Abstract: | Objective:To study the effect of paeonol on experimental atherosclerosis in quails caused by high lipid feeding.Method:The effects of oral administration of 300 and 600mg/kg of paeonol on lipid levels in serum,hemorrheology and aortic intimal abnormalities were investigated.Result:Paeonol decreased TC,TG,LDL,vLDL,APOB 100 levels in serum and TC levels in aorta and liver.The ratios of HDL/TC,HDL2/HDL3, apoA1/apoB100were elevated.In addition,the drug reduced the whole blood viscosity,Plasma viscosity and plasma fibrinogen,and inhibited erythrocyte aggregation.Conclusion:Oral administration of paeonol can reduce the development of atherosclerosis. |
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| Keywords: | paeonol atherosclerosis lipid hemorrheology |
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