| 光谱核型分析技术在白血病中的应用 |
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| 引用本文： | 郭搏,达万明,韩晓萍.光谱核型分析技术在白血病中的应用[J].中国实验血液学杂志,2006,14(3):619-622. |
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| 作者姓名： | 郭搏 达万明 韩晓萍 |
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| 作者单位： | 中国人民解放军总医院血液科,北京,100853 |
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| 摘 要： | 光谱核型分析技术是近几年建立的一种细胞遗传学检测方法,它可以在没有任何预知的情况下同时对人的24条染色体进行核型分析,可以识别常规显带和单纯应用荧光原位杂交难以精确辨认的一些畸变,具有高度的精确性、敏感性、直观性.本文综述了光谱核型技术的原理及其在白血病中的应用.
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| 关 键 词： | 光谱核型分析 染色体 核型 白血病 |
| 文章编号： | 1009-2137（2006）03-0619-04 |
| 收稿时间： | 2005-05-24 |
| 修稿时间： | 2006-02-27 |
Application of Spectral Karyotyping in Leukemia -- Review |
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| GUO Bo,DA Wan-Ming,HAN Xiao-Ping.Application of Spectral Karyotyping in Leukemia -- Review[J].Journal of Experimental Hematology,2006,14(3):619-622. |
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| Authors: | GUO Bo DA Wan-Ming HAN Xiao-Ping |
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| Institution: | Department of Hematology, The General Hospital of PLA, Beijing, 100853, China. |
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| Abstract: | Spectral karyotyping (SKY) is a novel cytogenetic technique, has been developed to unambiguously display and identify all 24 human chromosomes at one time without a priori knowledge of any abnormalities involved. SKY discerns the aberrations that can not be detected very well by conventional banding technique and fluorescent in situ hybridization (FISH). So SKY is hyper-accurate, hypersensitive, and hyper-intuitional. In this paper the basic principle of SKY technique and its application in leukemia cytogenetics were reviewed. |
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| Keywords: | spectral karyotyping chromosome karyotype leukemia |
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