Ion-pair formation as a strategy to enhance topical delivery of salicylic acid |
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Authors: | Megwa S A Cross S E Benson H A Roberts M S |
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Affiliation: | Department of Medicine, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Australia. |
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Abstract: | An in-vitro study was carried out to determine the possibility of improving the efficiency of transdermal delivery of salicylate through human epidermis by ion-pair formers (alkylamines and quaternary ammonium ions). Further, the relationship between the physicochemical properties of the counter-ions and salicylate flux was examined. It was found that flux can be related to the conductivity associated with the penetrant solution, molecular size of the counter-ion and lipophilicity expressed as either octanol/water partition coefficient of the ion pairs or the carbon chain-length of the counter-ions. Equations have been developed to predict salicylate flux from these physicochemical parameters. |
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