腰腿痛发病机制研究

椎间盘和椎间关节具有多重感觉神经支配,椎间盘的损伤和椎间关节的无菌性炎症产生疼痛,神经根的受压和炎症刺激使疼痛敏化。背根神经节是多种神经肽的制造场所和输送站,神经肽除了维持正常神经信息的传递、对伤害感受性感觉的神经递质的调节外,还具有血管活性作用,诱发神经源性神经肽介导的炎症损伤作用。反复的损伤和炎症刺激,可造成神经根与周围组织的粘连。以上因素均是产生腰腿痛的原因。

Pathological mechanism of low back pain

Both intervertebral disc and facet j oint dominated by duplicated sensory nerve.Injury and sterility inflam mation of them cause low back pain.Nerve root compressed and inflammation stimulated make it hyperalgesia.Dorsal root ganglia i s the place that produce many kind of neuropetide.Neuropetide have many functions,such as transmission of nerve information,adjustmen t neurotransmitter of injury re-ceptor and activity of blood vessel.Injury and stimulated by inflammation repeatedly cause adherence betwe en nerve root and its circumference tissue.Those are result in low back p ain.