Expression of fas ligand in human colon cancer cell lines |
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| Authors: | Jian-jun Zhang Er-xun Ding Qiang Wang Xue-yun Chen Zhi-ren Fu |
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| Institution: | (1) Department of General Surgery, Chang Zheng Hospital, Second Military Medical University, 200003 Shanghai;(2) Department of General Surgery, No. 150 Hospital of PLA, 471001 Luoyang |
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| Abstract: | Objective: To investigate the expression of Fas ligand in human colon carcinoma cell lines. Methods: A total of six human colon cancer cell lines were examined for the expression of Fas ligand mRNA and cell surface protein by using RT-PCR and flow cytometry respectively. Results: The results showed that Fas ligand mRNA was expressed in all of the six cancer cell lines and Fas ligand cell surface protein was expressed in part of them. Conclusion: These data suggest that Fas ligand was expressed, at least in part, in human colon cancer cell lines and might facilitate to escape from immune surveillance of the host. |
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| Keywords: | Fas ligand mRNA Cell surface protein Expression Colon cancer |
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