EXPRESSION OF CYCLIN D1 AND CDK4 IN OSTEOSARCOMA OF THE JAWS

The main cause of the cellular malignant proliferation is the disorder of cell division and growth. The alterations of proteins and genes that involved in this process correlate closely with the occurrence and vicious phenotype of neoplasm. Cyclin D1 and cyclin-dependent kinase 4 (CDK4) regulatory proteins in G1 phase have a direct bearing on carcinogenesis. Presently, gene amplification, overexpression, chromosome inversion andtranslocation of cyclin D1 and CDK4 have been discovered in ma…

Expression of cyclin D1 and CDK4 in osteosarcoma of the jaws

Objective: To analyze cyclin D1 and cyclin- dependent kinase 4 (CDK4) expression and their significance in osteosarcoma of the jaws. Methods: Immunohistochemical ABC method was used to detect the expression of cyclin D1 and CDK4 in 20 cases of osteosarcoma and 8 cases of osteochondroma of the jaws. Results: The positive rates of cyclin D1 and CDK4 were 65% (13/20) and 60% (12/20), respectively. There was significant positive correlation between cyclin D1 and CDK4 expression ((s=0.48, P<0.05). Both cyclin D1 and CDK4 were present in 1/8 (12.5%) osteochondroma. The positive rate was remarkably different between osteosarcoma and osteochondroma (P<0.05). Conclusion: Cyclin D1 and CDK4 are overexpressed in osteosarcoma of the jaws and closely related to its occurrence and development.