Synergistic efficacy of adenovirus-mediated BCL-XS gene transfer and topotecan in ovarian cancer cell |
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Authors: | He Wang Vicki V Baker |
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Affiliation: | (1) West China Second Hospital, Sichuan University, 610041 Chengdu, China;(2) University of Michigan Comprehensive Cancer Center, 48109-0724, MI, USA |
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Abstract: | Objective: To observe the synergistic efficacy between Adenovirus-mediated bcl-Xs(Adv-bcl-Xs) gene transfer and chemotherapy on ovarian cancer cell growth. Methods: NuTu-19 cells were infected by different titers of Adv-bcl-Xs and treated with topotecan in the meantime. Cell proliferation was measured 3 days later by MTT. Graphical representations and statistical analyses for their interaction in tumor cells were done. Results: The statistical result and Graphical representations of the statistical modeling showed synergy effect on cell growth inhibition (P<0.01). Conclusion: There were synergistic efficacies between Adv-bcl-Xs gene therapy and Topotecan in ovarian cancer cell growth. |
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Keywords: | bcl-Xs Topotecan Ovarian Cancer |
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