Antimetastatic effect of integrin IIb/IIIa inhibitors on salivary adenoid cystic carcinoma |
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Authors: | Feng-he Li Guang-yan YU Sheng-lin Li Shi-qi Peng Jia Fu |
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Affiliation: | (1) Peking University School of Stomatology, 100081 Beijing;(2) Peking University School of Pharmacology, 100083 Beijing |
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Abstract: | Objectives: To investigate the relation between metastatic potential of salivary adenoid cystic carcinoma (SACC) and tumor cell-platelet adhesion, and the antimetastatic effect of integrin IIb/IIIa inhibitor on SACC. Methods: Tumor cell-platelet adhesion of highly metastatic SACC-LM, non-highly metastatic SACC-83 and effect of aspirin, arginine-aspartate (RD), magnesium acetylsalicylate on adhesion were studied in vitro. Antimetastafic effect of aspirin, RD, magnesium acetysalicylate on experimental metastasis of SACC was observed in vivo. Results: The tumor cell-platelet adhesion was stronger in SACC-LM than in SACC-83. Aspirin, RD and magnesium acetylsalicylate could inhibit the adhesion of SACC-LM at the concentration of 1, 5 and 25 (g/ml. RD can inhibit experimental metastasis of SACC. Conclusion: Metastasis of SACC is related to platelet-tumor cell adhesion, RD could inhibit metastasis of SACC. |
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Keywords: | Salivary adenoid cystic carcinoma Integrin IIb/IIIa Platelet Neoplasm metastasis Nude mice |
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