| 松香基脲类衍生物的合成及其抗菌活性研究 |
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| 引用本文： | 廖迎,李芳耀,黄凤香. 松香基脲类衍生物的合成及其抗菌活性研究[J]. 华夏医学, 2007, 20(2): 209-211 |
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| 作者姓名： | 廖迎 李芳耀 黄凤香 |
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| 作者单位： | 桂林医学院药学院,广西,桂林,541004 |
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| 摘 要： | 目的：设计合成了一系列松香基脲类衍生物,初步研究了其抗菌活性。方法：以脱氢松香酸为起始原料,酰氯化后,经Curtius重排得到松香基异氰酸酯,然后与芳香胺反应得到松香基脲。结果：得到5个松香基脲类化合物,经IR、1H-NMR、元素分析等确证其结构。结论：初步药理实验表明,合成产物对金黄色葡萄球菌及大肠杆菌具有良好的抗菌活性。
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| 关 键 词： | 脱氢松香酸 脲 Curtius重排 抗菌活性 |
| 文章编号： | 1008-2409(2007)02-0209-03 |
| 修稿时间： | 2007-01-17 |
Synthesis and antibacterial activity of some urea from dehydroabietic acid |
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| LIAO Ying,LI Fang-yao,HUANG Feng-xiang. Synthesis and antibacterial activity of some urea from dehydroabietic acid[J]. Acta Medicinae Sinica, 2007, 20(2): 209-211 |
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| Authors: | LIAO Ying LI Fang-yao HUANG Feng-xiang |
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| Affiliation: | LIAO Ying,LI Fang-yao,HUANG Feng-xiangGuilin Medical College,Guilin 541004,China |
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| Abstract: | Objective:To design and synthesize a series of urea derivertives from dehydroabietic acid,and to determine their antibacterial activity.Methods:The urea derivertives were prepared by the acyl chloridate with dehydroabietic acid,Curtius rearrangement and then reaction with aromatic amine.Results:Five dehydroabietylureas were obtained and their structures were characterized by IR,1H-NMR and elemental analysis.Conclusion:Pharmacological tests inducated that these ureas possessed excellent inhibitive activity against S.aureus and E.Colt. |
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| Keywords: | dehydroabietic acid urea Curtius rearrangement antibacterial activity |
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