血管内皮生长因子-C与乳腺癌淋巴结转移关系的研究

目的 探讨血管内皮生长因子-C(vascular endothelial growth factor-C, VEGF-C)的表达与乳腺癌淋巴结转移的关系.方法 应用免疫组化法观察78例乳腺浸润性导管癌组织中VEGF-C的表达情况,评价VEGF-C表达与淋巴结转移及其他临床病理因素的关系.取20例乳腺纤维腺瘤标本做对照.结果 78例乳腺浸润性导管癌中52例VEGF-C呈阳性表达,阳性率为67%;对照组仅3例可见VEGF-C弱表达,阳性率为15%.乳腺癌组VEGF-C表达阳性率明显高于对照组,差异有统计学意义(P<0.01);乳腺癌腋淋巴结转移组VEGF-C表达阳性者阳性率(78%)明显高于腋淋巴结无转移组(48%),差异有统计学意义(P<0.05);VEGF-C表达与患者年龄、肿瘤大小、激素受体、及临床分期之间差异无统计学意义(P>0.05).结论 VEGF-C与乳腺癌淋巴结转移呈正相关,是乳腺癌重要预后因子.

Research of the relationship between vascular endothelial growth factor-C and lymph node metastasis of breast cancer

Objective To investigate the expression of VEGF-C in breast cancer and its relationship with lymph node metastasis. Methods VEGF-C expression was assessed by immunohistochemistry in 78 cases of breast cancer. The relationship between expression of VEGF-C and lymph node status and clinicopathological features in breast cancer was analyzed. 20 cases of breast fibroadenoma was taken as control group. Results The expression of VEGF-C was significantly higher in breast cancer group than that in fibroadenoma group(P<0.01). VEGF-C was significantly higher in axillary lymph node-positive group than that in axillary lymph node-negative group(P<0.05). No relativity was found between VEGF-C and patient age, tumor size, estrogen receptor status, progesterone receptor status, and clinical stage. Conclusion The high expression of VEGF-C has a relativity with lymph node metastasis of breast cancer and may be important for the breast cancer's prognosis.