| 血清Cyfra21-1和SELDI技术联合检测肺鳞癌的临床意义 |
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| 引用本文： | 刘枋,林志强,陈慧菁,林艳,林丽婷,陈强,叶韵斌.血清Cyfra21-1和SELDI技术联合检测肺鳞癌的临床意义[J].肿瘤防治研究,2011,38(5):539-541. |
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| 作者姓名： | 刘枋 林志强 陈慧菁 林艳 林丽婷 陈强 叶韵斌 |
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| 作者单位： | 1.350108 福州，福建医科大学;2.福建省肿瘤医院肿瘤免疫学研究室;3.福建中医学院附属人民医院 检验科；4.福建医科大学附属协和医院 |
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| 基金项目： | 福建省自然科学基金资助项目(X0750024) |
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| 摘 要： | 目的探讨血清Cyfra21-1和SELDI技术联合应用在肺鳞癌患者中的诊断意义。方法应用电化学发光技术对59例病理确诊肺鳞癌患者和60例健康对照者血清进行Cyfra21-1检测， 同时应用SELDI-TOF-MS和CM10芯片检测该血清，分析两种手段的联合诊断价值。结果电化学发光法单项检测Cyfra21-1的敏感度为77.966%、特异性为96.667%。应用SELDI技术以及肺鳞癌诊断模型进行分析，敏感度为83.051%、特异性为65.385%。而联合检测的敏感度为 94.915%、特异性为95.000%。结论与单用电化学发光法检测Cyfra21-1相比，联合SELDI技术检测更能提高肺鳞癌诊断的敏感度。联合检测的特异性也比单独使用SELDI技术有明显提高。
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| 关 键 词： | 肺鳞癌 SELDI Cyfra21-1 |
| 收稿时间： | 2010-05-05; |
Clinical Significance of Cyfra21-1 Analysis Combined with SELDI-TOF-MS Technology in Lung Squamous Carcinoma |
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| LIU Fang,LIN Zhi-qiang,CHEN Hui-jing,LIN Yan,LIN Li-ting,CHEN Qiang,YE Yun-bin.Clinical Significance of Cyfra21-1 Analysis Combined with SELDI-TOF-MS Technology in Lung Squamous Carcinoma[J].Cancer Research on Prevention and Treatment,2011,38(5):539-541. |
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| Authors: | LIU Fang LIN Zhi-qiang CHEN Hui-jing LIN Yan LIN Li-ting CHEN Qiang YE Yun-bin |
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| Institution: | 1.Fujian Medical University, Fuzhou 350108,China;2.Immuno Oncology Laboratory，Fujian Provincial Tumor Hospital;3.Clinical Laboratory，Fujian Traditional Medicine College Affiliated People’s Hospital;4.Fujian Medical University Union Hospital |
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| Abstract: | Objective To study the diagnostic values of co-detections of traditional serum tumor marker(Cyfra21-1) and serum proteomic patterns by surface-enhanced laser desorption and ionization time-flight mass spectrometry(SELDI-TOF-MS) technology in patients with lung squamous carcinoma.Methods Serum samples of 59 lung squamous carcinoma patients and 60 healthy controls were detected by electrochemiluminescence to analyze the levels of Cyfra21-1,meantime SELDI-TOF-MS and CM10-chips were employed to detect the diffe... |
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| Keywords: | Lung squamous carcinoma SELDI Cyfra21-1 |
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