| 胃癌组织中COX-2的表达及其与淋巴结转移相关性的Meta分析 |
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| 引用本文： | 曾金艳.胃癌组织中COX-2的表达及其与淋巴结转移相关性的Meta分析[J].肿瘤防治研究,2011,38(5):584-587. |
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| 作者姓名： | 曾金艳 |
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| 作者单位： | 214000 江苏无锡，无锡卫生高等职业技术学校外护公卫教研室 |
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| 摘 要： | 目的研究胃癌组织中环氧合酶-2（COX-2）的表达及其与淋巴结转移之间的关系。方法综合分析自2005年1月至今公开发表的有关COX-2与胃癌发生、淋巴结转移关系的文献资料，按照文献入选标准，有13项随机对照实验纳入本次研究，应用RevMan5.0.17软件进行统计分析。结果COX-2在胃癌组织中的表达显著高于正常组织，OR=24.70，95%CI：15.93~38.31，在肿瘤转移组中COX-2的表达明显高于非转移组，OR=4.94，95%CI：3.50~6.77。结论COX-2高表达与胃癌的发生有统计学关联，并与淋巴结转移相关。
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| 关 键 词： | 胃癌 COX-2 淋巴结转移 Meta分析 |
| 收稿时间： | 2010-04-26; |
A Meta Analysis of Relationship between COX-2 Expression and Lymph Node Metastasis in Gastric Cancer |
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| ZENG Jin-yan.A Meta Analysis of Relationship between COX-2 Expression and Lymph Node Metastasis in Gastric Cancer[J].Cancer Research on Prevention and Treatment,2011,38(5):584-587. |
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| Authors: | ZENG Jin-yan |
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| Institution: | Staff Room of Surgical Nursing and Public Health,Wuxi Higher Health Vocational Technology School, Wuxi 214000,China |
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| Abstract: | ObjectiveTo investigate the relationship between COX-2 expression and lymph node metastasis in gastric cancer．MethodsAll available literatures using randomized clinical controlled trails including COX-2, lymph node metastasis in gastric carcinoma from January 2005 to 2009 were analyzed．According to the inclusion criteria, 13 studies were selected and data analyzed by RevMan 5.0.17 software．ResultsCOX-2 in gastric cancer tissues was significantly higher than that in normal tissues, OR=24.70,95% CI：15.93~38.31. In the tumor metastasis group COX-2 expression was significantly higher compared with no metastasis group, OR=4.94,95% CI： 3.50~6.77.ConclusionOver-expression of cyclooxygenase-2 significantly related to gastric carcinoma and lymph node metastasis. |
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| Keywords: | Gastric cancer Cyclooxygenase-2 Lymph node metastasis Meta-analysis |
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