| 巨噬细胞抑制因子-1在老年晚期非小细胞肺癌表达的临床意义 |
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| 引用本文： | 王志东,刘湘国,田晓彩,唐建明,李泉清,刘蒸生.巨噬细胞抑制因子-1在老年晚期非小细胞肺癌表达的临床意义[J].中国医疗前沿,2012(11):7-9. |
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| 作者姓名： | 王志东 刘湘国 田晓彩 唐建明 李泉清 刘蒸生 |
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| 作者单位： | 湖南省老年医院肿瘤内科 |
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| 基金项目： | 湖南省中医药科研计划项目(编号:2008044) |
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| 摘 要： | 目的探讨巨噬细胞抑制因子-1(Macrophage inhibitory cytokine-1,MIC-1)在老年晚期非小细胞肺癌中表达与病理特征的相关性。方法用免疫组化法检测60例老年晚期非小细胞肺癌组织MIC-1的表达,并进行临床病理因素相关性分析。结果 MIC-1在老年晚期非小细胞肺癌组织表达,阳性表达率与临床分期相关。结论 MIC-1可作为评价老年晚期非小细胞肺癌发生、发展的生物学指标,为寻找老年晚期非小细胞肺癌新的治疗手段提供依据。
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| 关 键 词： | 老年晚期非小细胞肺癌 巨噬细胞抑制因子-1 TNM分期 |
Clinical Signifcance of the Expression of MIC-1 Genes in elder advanced Non-smail Lung Cancer |
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| Institution: | WANG Zhi-Dong,LiIU Xiang-guo,TIAN Xiao-Cai,et al.Medical Oncology dePartment,Gerontological HosPital of Hunan Province,Changsha 410016,China |
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| Abstract: | Objective To investigate the correlations between the expressions of Macrophage inhibitory cytokine1(MIC-1) gene and clinicpat hologic feature in patients with elder advanced non-small lung cancer.Methods The expressions of MIC-1 in 60 patients with elder advanced non-small lung cancer were assessed by immunohistochemistry method,and their correlations with clinical pathologic factors were statistically analyzed.Results The results showed that the expressions of MIC-1 in elder advanced non-small lung cancer had significant correlation with clinical stage.There was a significant linear relationship between levels of the MIC-1 oncoprotein and clinical stage in patients with elder advanced non-small lung cancer.Conclusion The expression of MIC-1 may be regarded an objective biological marker for estimating the occurrence and progression of elder advanced non-small lung cancer. |
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| Keywords: | Elder advanced non-smal lung cancer Macrophage inhibitory cytokine-1 TNM stage |
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