Characterization of histamine secretion induced by anthracyclines in rat peritoneal mast cells |
| |
| Authors: | G Decorti F Bartoli Klugmann L Candussio L Baldini |
| |
| Affiliation: | 1. Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia;2. Heart Failure Pharmacology, Baker Heart & Diabetes Institute, Melbourne, VIC 3004, Australia;1. Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand;2. Department of Pharmacology, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand;3. Center of Biopharmaceutical Science for Healthy Ageing (BSHA), Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand;1. Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA |
| |
| Abstract: | The histamine-releasing activity of three anthracyclines, adriamycin, daunomycin and epirubicin, has been tested on rat peritoneal mast cells. The three drugs induced a marked and dose-dependent histamine secretion, in a noncytotoxic manner. The release was not sustained by extracellular calcium but was largely dependent on intracellular stores of this cation. This function was blocked by extremes of temperature (0 and 45 degrees), was very rapid and virtually complete within 10 sec. Treatment of mast cells with theophylline or disodium cromoglycate significantly reduced the secretory response to anthracyclines. On the basis of these results it is clear that the stimulant effect of anthracyclines is a true exocytotic response and thus is very similar to that of the classic mast cell secretagogue, compound 48/80. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
