| 单唾液酸四己糖神经节苷脂治疗新生儿缺氧缺血性脑病临床疗效 |
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| 引用本文： | 赵幽燕,平 鹦,封 云,孙晓丽.单唾液酸四己糖神经节苷脂治疗新生儿缺氧缺血性脑病临床疗效[J].药学与临床研究,2010,18(1):67-69. |
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| 作者姓名： | 赵幽燕 平 鹦 封 云 孙晓丽 |
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| 作者单位： | 南京医科大学附属南京儿童医院新生儿科,南京,210008 |
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| 摘 要： | 目的探讨单唾液酸四己糖神经节苷脂（GM1）治疗新生儿缺氧缺血性脑病的临床疗效。方法：48例新生儿缺氧缺血性脑病患儿，随机分为治疗组25例，对照组23例，两组均采用常规治疗，治疗组在常规治疗基础上加用GM1静脉滴注，1次／天，20mg／次，10～14天为一疗程。比较两组患儿治疗前后新生儿神经行为评分（NBNA）及CT测量值。结果：两组患儿治疗5～7天和治疗10～14天NBNA评分有显著差异．且治疗组评分明显高于对照组。两组患儿治疗前和治疗一疗程CT值均无显著差异（P〉0．05），出生后28天治疗组CT值明显高于对照组（P〈0．05）。结论：GM1治疗新生儿缺氧缺血性脑病疗效显著，未见不良反应发生。
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| 关 键 词： | 新生儿 缺氧缺血性脑病 神经节苷脂 |
| 收稿时间： | 2009/10/12 0:00:00 |
| 修稿时间： | 2009/11/28 0:00:00 |
Clinical Study on Treatment of Neonatal Hypoxic-Ischemic Encephalopathy with Monosialotetrahexosylganglioside |
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| ZHAO You-yan,PING Ying,FENG Yun and SUN Xiao-li.Clinical Study on Treatment of Neonatal Hypoxic-Ischemic Encephalopathy with Monosialotetrahexosylganglioside[J].Pharmacertical and Clinical Research,2010,18(1):67-69. |
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| Authors: | ZHAO You-yan PING Ying FENG Yun and SUN Xiao-li |
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| Institution: | ZHAO You-yan,PING Ying,FENG Yun,SUN Xiao-li Department of Neonatology,Nanjing Children\'s Hospital Affiliated to Nanjing Medical University,Nanjing 210008,China |
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| Abstract: | Objective :To investigate the clinical curative effect of monosialotetrahexosylganglioside(GM1) on neonatal hypoxic-ischemic encephalopathy.Methods:Forty-eight cases were randomly divided into two groups,25 cases in treatment group and 23 cases in control group.Both groups received routine treatment,while GM1 was added in the treatment group 20mg once a day,10-14 days a course.Neonatal behavior neurological assessment(NBNA) scores and CT values were compared between the two groups before or after treatment.... |
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| Keywords: | Neonate Neonatal hypoxic-ischemic encephalopathy Monosialotetrahexosylganglioside(GM1) |
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