靶向骨髓微环境治疗多发性骨髓瘤的进展

多发性骨髓瘤(MM)仍是一种不能治愈的血液系统肿瘤。在MM的发病过程中,除了基因染色体的突变,MM瘤细胞与骨髓微环境的交流也扮演了极其重要的角色。骨髓微环境里各种成分能通过多条信号转导通路的异常活化从而促进MM瘤细胞的生存、增殖、迁移、耐药。这些年来,研究MM与骨髓微环境的关系,使用靶向药物针对性地治疗各条异常活化的信号通路已成为治疗MM的热点。弄清MM在骨髓中的发病机制,提高靶向治疗的针对性,增强药物对MM细胞的毒性,防止耐药,改善患者的预后已成为今后研究的热点课题。

Targeting the Bone Marrow Micro-environment for the Treatment of Multiple Myeloma

Multiple myeloma(MM)is still an incurable malignancy.In the pathogenesis of MM,in addition to gene mutations,the communication of MM tumor cells and bone marrow micro-environment also played an extremely important role.Various components of the bone marrow micro-environment through a number of abnormal activation of signal transduction pathways so as to promote the survival of MM tumor cells,proliferation,migration,drug-resistant.These days,study MM and bone marrow micro-environment relations,the use of dru...