| 疏血通对2型糖尿病合并冠心病患者血浆PAI-1及D-二聚体作用的临床观察 |
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| 引用本文： | 张冬梅,陈明,张后民.疏血通对2型糖尿病合并冠心病患者血浆PAI-1及D-二聚体作用的临床观察[J].重庆医学,2010,39(1). |
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| 作者姓名： | 张冬梅 陈明 张后民 |
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| 作者单位： | 重庆医科大学附属第一医院心内科,400016;重庆医科大学附属第一医院心内科,400016;重庆医科大学附属第一医院心内科,400016 |
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| 摘 要： | 目的观察疏血通治疗糖尿病合并冠心病血浆纤溶酶原活化物抑制剂-1(PAI-1)及D-二聚体(DD)变化并观察其心绞痛及心电图ST-T的改善。方法将糖尿病合并冠心病患者120例随机分为治疗组60例(在冠心病常规二级预防的基础上加用疏血通治疗14d),对照组(冠心病常规二级预防)60例,分别观察两组治疗前后血浆PAI-1、DD、血浆凝血酶原时间(PT),活化的部分凝血活酶时间(APTT)、国际标准化比值(INR)的变化;心绞痛症状及心电图ST-T改善情况。结果治疗组治疗后PAI-1下降(P<0.05),PT、APTT、INR延长(P<0.05),15例(25%)患者DD值较治疗前升高,但差异无统计学意义(P>0.05),45例(75%)患者较治疗前降低,差异具有统计学意义(P<0.05)。对照组PAI-1、DD、PT、APTT、INR的变化差异无统计学意义,治疗组心绞痛症状及心电图的ST-T较对照组有明显改善。结论疏血通可安全有效降低2型糖尿病合并冠心病患者血浆PAI-1、DD,延长PT、APTT、INR,并明显改善2型糖尿病合并冠心病患者心绞痛症状及心电图ST-T。
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| 关 键 词： | 疏血通 2型糖尿病 冠心病 血浆纤溶酶原活化物抑制剂-1 D-二聚体 |
Effects of Shuxuetong on plasma PAI-1 and D-dimer in type 2 diabetic patients with coronary heart disease |
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| ZHANG Dong-mei,CHEN Ming,ZHANG Hou-min.Effects of Shuxuetong on plasma PAI-1 and D-dimer in type 2 diabetic patients with coronary heart disease[J].Chongqing Medical Journal,2010,39(1). |
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| Authors: | ZHANG Dong-mei CHEN Ming ZHANG Hou-min |
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| Institution: | Department of Cardiology;First Affiliated Hospital;Chongqing Medical University;Chongqing 400016;China |
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| Abstract: | Objective To investigate the effects and mechanisms of Shuxuetong on type 2 diabetic patients with coronary heart disease.Methods The 120 type 2 diabetic patients combined with coronary heart disease were randomly divided into treatment group and control group:the 60 of them were treated with routine western medicine(control group)and the other 60 patients(treatment group)were treated with Shuxuetong on the base of routine medicine for 14d.PAI-1,DD,PT,APTT,INR levels were examined and angina symptoms and EC... |
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