| CD4~+CD25~+调节性T细胞和Foxp3在不同病理类型乳腺癌患者外周血和组织中表达水平及其临床意义 |
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| 引用本文： | 甘长清,王小毅. CD4~+CD25~+调节性T细胞和Foxp3在不同病理类型乳腺癌患者外周血和组织中表达水平及其临床意义[J]. 免疫学杂志, 2009, 25(3) |
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| 作者姓名： | 甘长清 王小毅 |
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| 作者单位： | 重庆医科大学第一附属医院普外科 |
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| 摘 要： | 目的 探讨乳腺癌(breast cancer)患者外周血和乳腺组织中CD4+ CD25+、Foxp3 mRNA和蛋白水平表达情况,初步阐明二者在乳腺癌患者免疫调节中的作用和意义.方法 选取乳腺癌患者25例,15例正常乳腺组织作为对照.采用流式细胞术检测乳腺癌患者外周血中CD4+ CD25+ Treg的表达水平.RT-PCR和Western blot分别用于检测患者癌变组织中Voxp3mRNA和蛋白表达水平.结果 相对于正常对照组,各组乳腺癌患者外周血中CD4+ CD25+ Treg表达水平明显升高(P＜0.05);同时,乳腺癌各组中Foxp3 mRNA和蛋白表达水平均明显升高(P＜0.05,P＜0.01).结论 CD4+ CD25+ Treg和其标记分子Foxp3可能参与了乳腺癌中机体的免疫调节过程,其二者表达水平的检测对于乳腺癌临床判断和进一步的治疗具有一定指导意义.
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| 关 键 词： | 乳腺癌 CD4 CD25 T调节细胞 病理类型 |
Expression levels of CD4~+CD25~+ regulatory T cell and Foxp3 in peripheral blood and different pathological mammary gland tissues of breast cancer patients and investigation of the clinical significance |
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| GAN Changqing,WANG Xiaoyi. Expression levels of CD4~+CD25~+ regulatory T cell and Foxp3 in peripheral blood and different pathological mammary gland tissues of breast cancer patients and investigation of the clinical significance[J]. Immunological Journal, 2009, 25(3) |
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| Authors: | GAN Changqing WANG Xiaoyi |
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| Affiliation: | GAN Changqing,WANG Xiaoyi Department of General Sugery,First Affiliated Hospital,Chongqing Medical University,Chongqing 400042,China |
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| Abstract: | Objective To investigate the expressions of CD4+CD25+ regulatory T cell(Treg) and Foxp3 in peripheral blood and mammary gland tissues of breast cancer patient with different pathological types and illuminate the effect and the significance in immunological regulation. Methods Total of 35 breast cancer tissue samples including 25 infitrating ductal carcinoma,4 infiltrating lobular carcinoma,4 colloid carcinoma,and 2 carcinoma medullare were selected according to 6th Edition of AJCC Cancer Staging Manual for ... |
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| Keywords: | Foxp3 |
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