Growth hormone treatment on atherosclerosis: results of a 5-year open, prospective, controlled study in male patients with severe growth hormone deficiency |
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| Authors: | Colao Annamaria Di Somma Carolina Spiezia Stefano Savastano Silvia Rota Francesca Savanelli Maria Cristina Lombardi Gaetano |
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| Affiliation: | Department of Molecular and Clinical Endocrinology and Oncology, "Federico II" University of Naples, via S. Pansini 5, 80131 Naples, Italy. colao@unina.it. |
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| Abstract: | Background: Severe GH deficiency (GHD) is associated with, increased cardiovascular risk and intima-media thickness (IMT) at major arteries. Objective: The objective of the study was to investigate the 5-yr effects of GH replacement on common carotid IMT and insulin resistance syndrome (IRS) (at least two of the following: triglycerides levels >/= 1.7 mmol/liter, high-density lipoprotein-cholesterol levels
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