| 两种测定盐酸噻氯匹定胶囊溶出度方法的比较 |
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| 引用本文： | 刘德胜,徐玉文,栾海云,云飞,陈向明.两种测定盐酸噻氯匹定胶囊溶出度方法的比较[J].中国药品标准,2011,12(2):141-144. |
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| 作者姓名： | 刘德胜 徐玉文 栾海云 云飞 陈向明 |
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| 作者单位： | 1. 滨州医学院药学院,山东烟台,264003
2. 山东省药品检验所,济南,250101 |
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| 摘 要： | 目的:建立HPLC法测定盐酸噻氯匹定胶囊溶出度,与UV法比较溶出度测定的差异。方法:采用ODS-3 C18色谱柱,柱温35℃,流动相为0.022%戊烷磺酸钠溶液-磷酸盐缓冲液-甲醇-乙腈(26∶55∶23∶15),流速1.0 mL.min-1,检测波长220nm。结果:盐酸噻氯匹定在0.05~0.15 mg.mL-1浓度范围内与峰面积呈良好的线性关系(r=0.999 9)。结论:该法灵敏、准确,适用于盐酸噻氯匹定胶囊溶出度的测定。
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| 关 键 词： | 盐酸噻氯匹定胶囊 溶出度 UV法 HPLC法 |
Comparison on two Dissolution Methods of Ticlopidine Hydrochloride Capsules |
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| Authors: | Liu De-sheng Xu Yu-wen Luan Hai-yun Yun Fei and Chen Xiang-ming |
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| Institution: | Liu De-sheng 1,Xu Yu-wen2,Luan Hai-yun,Yun Fei1,Chen Xiang-ming1(1.Collge of Pharmacy,Binzhou Medical College,Yantai 264003,2.Shandong Provincial Institute for Drug Control,Jinan 250101) |
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| Abstract: | To establish an HPLC method for the determination of dissolution in Ticlopidine Hydrochloride Capsules by comparison two dissolution methods of ticlopidine hydrochloride capsules. A ODS-3 C18 column with UV detection at 220 nm, and a mixture of 0. 022% sodium pentanesulfonate solution -phosphate BS -methanol-acetonitrile （26： 55：23：15 ） as the mobile phase were used. The flow rate was 1.0 mL · min - 1, and the temperature of the column was 35℃. An excellent separation was achieved for Ticlopidine Hydrochloride and excipient, the calibration curve was linear in the range of 0. 05 - 0. 15 mg · mL-1 of Ticlopidine Hydrochloride, r = 0. 999 9. This method was accurate, simple, quick and effective for determination of dissolution in Ticlopidine Hydrochloride Capsules. |
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| Keywords: | Ticlopidine Hydrochloride Capsules dissolution UV HPLC |
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