| PDGFRB基因易位的不典型慢性髓细胞白血病的临床观察 |
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| 引用本文： | 吕书晴,龚胜蓝,杨建民,黄崇媚,韩凤来,王健民. PDGFRB基因易位的不典型慢性髓细胞白血病的临床观察[J]. 临床肿瘤学杂志, 2011, 16(5): 444-448 |
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| 作者姓名： | 吕书晴 龚胜蓝 杨建民 黄崇媚 韩凤来 王健民 |
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| 作者单位： | ２００４３３ 上海 第二军医大学长海医院血液内科 |
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| 摘 要： | 目的 探讨涉及PDGFRB基因易位的不典型慢性髓细胞白血病(CML)的诊断和治疗.方法 对1例不典型CML患者进行骨髓细胞染色体核型分析,RT-PCR检测bcr/abl融合基因,荧光原位杂交(FISH)检测PDGFRB基因易位,羟基脲和干扰素治疗并观察疗效.结果 该例患者的骨髓细胞染色体核型为46,XY,t(5;12)...
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| 关 键 词： | 慢性髓细胞白血病 PDGFRB 酪氨酸激酶抑制剂 伊马替尼 |
| 收稿时间： | 2010-09-25 |
| 修稿时间： | 2011-01-04 |
Clinical observation of atypic chronic myeloid leukemia involving translocation of PDGFRB gene |
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| LV Shu-qing,GONG Sheng-lan,YANG Jian-min,HUANG Chong-mei,HAN Feng-lai,WANG Jian-min. Clinical observation of atypic chronic myeloid leukemia involving translocation of PDGFRB gene[J]. Chinese Clinical Oncology, 2011, 16(5): 444-448 |
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| Authors: | LV Shu-qing GONG Sheng-lan YANG Jian-min HUANG Chong-mei HAN Feng-lai WANG Jian-min |
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| Affiliation: | LV Shu-qing,GONG Sheng-lan,YANG Jian-min,HUANG Chong-mei,HAN Feng-lai,WANG Jian-min.Department of Hematology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China |
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| Abstract: | Objective To introduce the diagnosis and treatment of patients with atypic chronic myeloid leukemia(CML) involving the translocation of platelet-derived growth factor receptor beta(PDGFRB) gene.Methods Cytogenetic studies,bcr/abl fusion gene detecting by RT-PCR,PDGFRB gene detecting by fluorescence in situ hybridization(FISH) of bone marrow cells from a patient with atypic CML were demonstrated.This patient was treated with hydroxycarbamide and interferon.Results The karyotype of bone marrow cells was 46,XY... |
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| Keywords: | PDGFRB |
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