门脉高压症选择性贲门周围血管离断术后血浆ET-1、NO水平的变化

目的:观察肝硬化门静脉高压症患者血浆内皮素-1(endothelin-1,ET-1)、一氧化氮(nitric oxide,NO)水平,探讨ET-1、NO水平与疾病严重程度和手术治疗效果的关系.方法:采用放射免疫分析和Griss方法,对治疗前的92例肝硬化门静脉高压症患者进行血浆ET-1、NO测定;并对66例接受选择性贲...

The Alterations of Plasma ET-1 and NO Post Selective Pericardial Devascularization in Patients with Hepatic Portal Hypertension

Objective To investigate the alterations of plasma endothelin-1(ET-1) and nitric oxide(NO) post the selective pericardial devascularization in patients with hepatic portal hypertension,and to investigate the relationship between such alterations with illness and therapeutic effects.Methods Before treatment,plasma ET-1 and NO contents were determined by radioimmunoassay(RIA) and Griss method respectively in 92 patients with hepatic portal hypertension.One day and three weeks after operation,66 operated cases with selective pericardial devascularization in patients with hepatic protal hypertension were also determined the levels of plasma ET-1 and NO with RIA.Results The levels of plasma ET-1 and NO were increased in 92 patients with hepatic portal hypertension,and which closely related to the stage of illness.Post effective selective pericardial devascularization the high levels of plasma ET-1 and No were improved and were closely returned to normal after 3 week’s.Conclusion Clinical detection of plasma ET-1 and NO levels were useful for assessment of the therapeutic effects of selective pericardial devascularization in patients with hepatic portal hypertension.