| 小剂量奥沙利铂化疗对小鼠H22肝癌乏氧的影响 |
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| 引用本文： | 张启佳,钱晓萍,刘宝瑞,胡静,禹立霞.小剂量奥沙利铂化疗对小鼠H22肝癌乏氧的影响[J].临床肿瘤学杂志,2011,16(5):407-411. |
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| 作者姓名： | 张启佳 钱晓萍 刘宝瑞 胡静 禹立霞 |
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| 作者单位： | ２１０００８ 南京 南京大学医学院附属鼓楼医院肿瘤中心 |
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| 摘 要： | 目的 观察小剂量奥沙利铂化疗对小鼠H22肝癌乏氧动态变化的影响,并探讨乏氧改变与其抗血管生成效应的关系.方法 建立小鼠H22肝癌皮下移植瘤模型,将成瘤小鼠随机分成对照组(5%葡萄糖20ml/kg)和治疗组(奥沙利铂1.5mg/kg),分别隔日腹腔给药(设为d0、d2、d4、d6).于d1、d3、d5、d7、行(99m)...
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| 关 键 词： | 抗血管生成 化学治疗 乏氧 奥沙利铂 H22肝癌细胞 |
| 收稿时间： | 2010-12-08 |
| 修稿时间： | 2011-01-19 |
The influence of low dose oxaliplatin chemotherapy on hypoxia in mouse H22 liver cancer |
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| ZHANG Qi-jia,QIAN Xiao-ping,LIU Bao-rui,HU Jing,YU Li-xia.The influence of low dose oxaliplatin chemotherapy on hypoxia in mouse H22 liver cancer[J].Chinese Clinical Oncology,2011,16(5):407-411. |
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| Authors: | ZHANG Qi-jia QIAN Xiao-ping LIU Bao-rui HU Jing YU Li-xia |
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| Institution: | ZHANG Qi-jia,QIAN Xiao-ping,LIU Bao-rui,HU Jing,YU Li-xia.Cancer Center,Drum Tower Hospital Affiliated to Medical College of Nanjing University,Nanjing 210008,China |
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| Abstract: | Objective To observe the influence of low dose oxaliplatin chemotherapy on dynamic oxygenation change within tumors and explore the relation between hypoxia and antiangiogenic effect.Methods Mouse tumor model was established by implanting H22 mouse hepatocarcinoma cells under skin.Experimental mice were randomly divided into two groups,including control group(5% glucose intraperitoneal injection,20ml/kg) and treatment group(1.5mg/kg oxaliplatin).Drug was given on d0,d2,d4 and d6.Tumors were imaged using 99m... |
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| Keywords: | Antiagniogenesis Chemotherapy Hypoxia Oxaliplatin H22 hepatocarcinoma cell line |
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