老年人非酒精性脂肪肝病与代谢综合征的相关研究

目的调查老年体检人员非酒精性脂肪肝病（NAFLD）和代谢综合征（MS）及其相关疾病的情况。方法从参与本院体检的405名60岁及以上的老年人中选取313例（男224例，女89例），平均76．08±7．53岁，检测身高、体重、腰围、体质指数（BMI）、空腹血糖、总胆固醇、甘油三脂、高密度脂蛋白及多普勒超声，并对结果分析。结果老年男、女性MS患病率分别为14．3％和20．2％，男、女NAFLD患病率为40．2％、36．0％。在MS各种组合中，男、女性均以肥胖、高血压、高血脂组合比例最高，占40％以上，NAFLD患病率在肥胖、高血压、高血脂、血糖异常组合中高达100％。NAFLD病人中的脑梗死、糖尿病、高血压比例较高，NAFLD病人的空腹血糖、甘油三酯、BMI、腰围也、显著高于非NAFLD，但血清胆固醇差异无统计学意义。NAFLD和MS相关（r=0．374，P〉0．01）。结论60岁及以上老年人的NAFLD和MS患病率均较高，NAFLD作为MS的一个组成部分应及早干预治疗。

Correlation between non-alcoholic fatty liver disease and metabolic syndrome in the elderly patients

Objective To investigate the relationship between nonalcoholic fatty liver disease （NAFLD） and metabolic syndrome （MS） in the elderly people. Methods 313 elderly people （male 224, female 89, mean age 76.08 ±7.53 years） from 405 elderly people who underwent health check were retrospectively studied. The levels of height, weight, waistline, body mass index （BMI）, fasting blood glucose, cholesterol, triglyceride, high-density lipoprotein and doppler image were assessed and analyzed, respectively. Results The prevalence of MS in elderly men and women was 14.3 % and 20.2 %. The incidence of NAFLD in men and women was 40.2% and 36.0%. The common manifestation of MS was obesity plus hypertension plus dyslipidemia, which ratio was over 40%. The proportion of NAFLD was 100% in the type which included obesity, hypertension, dyslipidemia, high plasma glucose. Patients with stroke, diabetes mellitus, hy- pertension were more in the NAFLD patients. The fasting blood glucose, triglyceride, BMI, waistline of the NAFLD group were higher than the no-NAFLD group, but the serum cholesterol had no obvious difference between the two groups. NAFLD was positively related with MS （ r=0.374, P〈0.01 ）. Conclusion The prevalence of MS and NAFLD is higher in the elder people. NAFLD is a part of MS, which needs interventional treatment early.