| HPLC法测定盐酸去氯羟嗪的有关物质 |
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| 引用本文： | 刘菲. HPLC法测定盐酸去氯羟嗪的有关物质[J]. 中国药品标准, 2011, 12(2): 89-90 |
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| 作者姓名： | 刘菲 |
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| 作者单位： | 辽宁省食品药品检验所,沈阳,110023 |
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| 摘 要： | 目的:建立高效液相色谱法测定盐酸去氯羟嗪中的有关物质.方法:采用C18柱,以甲醇-水-三乙胺(42:58:0.5)(用磷酸调节pH值至3.0)为流动相,检测波长为225nm.结果:盐酸去氯羟嗪与其降解产物在该色谱条件下能够有效分离.结论:方法简便、专属性强,可用于测定盐酸去氯羟嗪中有关物质.
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| 关 键 词： | 盐酸去氯羟嗪 有关物质 |
Determination of Related Substances in Decloxizine Hydrochloride by HPLC |
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| Liu Fei. Determination of Related Substances in Decloxizine Hydrochloride by HPLC[J]. , 2011, 12(2): 89-90 |
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| Authors: | Liu Fei |
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| Affiliation: | Liu Fei(Liaoning Provincial Institute for Food and Drug Control,Shenyang 110023) |
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| Abstract: | Objective：To establish an HPLC method for determining related substances in Decloxizine Hydrochloride. Methods：Using HPLC with C18column, methanol-water-triethanolamine （42： 58： 0. 5） （adjusted to pH 3.0 with phosphoric acid） as the mobile phase and the detection wavelenghth at 225 nm. Results：Deeloxizine Hydrochloride and its related substance can be separated effectively by this method. Conclusion：The method is simple and reliable. Related substances in Decloxizine Hydroehloride can be determined by HPLC. |
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| Keywords: | HPLC |
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