糖尿病前期人群血脂谱变化特点及其意义

目的了解糖尿病前期人群血脂谱、临床指标变化特点及意义。方法选择体柃的2212例有完整OGTT试验结果人群为研究对象，分为正常、糖尿病前期和糖尿病三组，对体检资料进行分析整理，并比较各组血脂谱变化及其他临床指标。结果糖尿病前期组血总胆固醇和低密度脂蛋白胆固醇比正常组增高（5．18±1．15vs4．96±1．04，3．17±0.93vs3．00±0．93，均P〈0．01），糖尿病前期组血高密度脂蛋白胆固醇较正常组降低（1．27-1-0．34vs1．30±O．29，P〈0．05）；糖尿病前期组血甘油三酯较正常组增高，但差异无统计学意义（1．73±1．19vs1．67土4．70，P〉0．05）。糖尿病组血脂异常较糖尿病前期组更明显，并与其变化趋势一致。除糖尿病家族史外，糖尿病前期组年龄、高血压病史、BMI、腰围、血压与正常组比较都明显异常，差异有统计学意义俨〈0．05）。结论糖尿病前期即合并脂代谢异常，需尽早加强调脂治疗力度。

The characteristic of serum lipoprotein spectrum in the pre-diabetes people

Objective To investigate the characteristic and changes of serum lipoprotein spectrum in the prediabetes pe- ople. Methods According to oral glucose tolerance test （OGTT）, 2 212 examinees aged 20-75 years were classified into the following three groups： normal glucose tolerance （NGT）, pre-diabetes and diabetes. The fasting lipids and clinical data among three groups were compared. Results Compared with those of NGT group, subjects in pre-diabetes group had higher levels in total cholesterol （TC） （5.18±1.15 vs 4.96±1.04） mmol/ L, and low density lipoprotein-cholesterol （LDL-C） （3.17±0.93 vs 3.00±0.93） （P〈0.01）, but high density lipoprotein-cholesterol （HDL-C） decreased （1.27±0.34 vs 1.30±0.29） （P〈0.05）. There were no differences in total triglyceride （TG） between NGT and pre-diabetes groups （1.73±1.19 vs 1.67±4.70, P〉0.05）. The dyslipidemia was more obvious in the diabetes groups than the pre-diabetes group. Age, hypertension, BMI, waist circumference and blood pressure were obviously abnormal in the pre-diabetes group, compared with the NGT group, excepted diabetes family history. Conclusions Diabetic dyslipidemia exists in the pre-diabetes people. The therapy for dyslipidemia may be beneficial in the pre-diabetes people, and should be considered routinely for all the pre-diabetes and the diabetic patients.