甲型副伤寒爆发疫情中病例的耐药特征和治疗效果评估

目的描述甲型副伤寒爆发疫情中病例的耐药特征和评估治疗效果。方法对爆发疫情中分离出的菌株进行药敏试验。计算从确诊病例治疗到体温正常所需的时间，以及通过粪检检查病例在完成治疗1周后是否继续排菌。结果所分离培养出的48株甲型副伤寒沙门菌有47株对萘啶酮酸耐药。48例确诊病例从治疗到体温恢复正常平均所需的时间为4．8d。所有确诊病人体温恢复正常1周后进行初次粪检仍有10％的病例继续排菌。消除病例带菌状态，从治疗时间算起，最长需要治疗60d。结论彻底消除甲型副伤寒带菌状况比较困难，需进一步研究更有效的治疗方案。

Drug resistant pattern of Salmonella paratyphi A cases from an outbreak and assessment of treatment outcome

Objective To describe drug resistance pattern and assess the outcome in treatment of Salmonella paratyphi A eases. Methods Salmonella paratyphi A strains isolated from outbreak was tested, fever clearance time of confirmed case was recorded. Results Out of 48 Salmonella paratyphi A strains isolated,47 strains was resistant to nalidix acid. The average fever clearance time was 4.8 days. 10% of all confirmed patients were still shedding strains in first stool excreted a week after fever clearance.. Sixty days was needed to clear Salmonella paratyphi. Conclusion It was difficult to clear the Salmonella paratyphi from the patients , thus effective therapies be explored.