| 金樱子醇提物对被动型Heymann肾炎大鼠的药理作用研究 |
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| 引用本文： | 陈敬民,李友娣. 金樱子醇提物对被动型Heymann肾炎大鼠的药理作用研究[J]. 中药材, 2005, 28(5): 408-410 |
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| 作者姓名： | 陈敬民 李友娣 |
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| 作者单位： | 广西中医药研究所,广西南宁,530022 |
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| 基金项目： | 广西科技厅青年科学基金 |
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| 摘 要： | 目的:研究金樱子醇提物对被动型Heymann肾炎(Passive Heymann Nephritis, PHN)大鼠的药理作用.方法:经尾静脉注射兔抗鼠血清诱发PHN大鼠,对PHN大鼠灌胃给予金樱子醇提物四周,观察金樱子醇提物对PHN大鼠的尿肌酐、尿蛋白及血清总蛋白、肌酐和尿素氮的作用.结果:金樱子醇提物显著降低被动型Heymann肾炎模型大鼠尿蛋白、血清肌酐和尿素氮水平,升高血清总蛋白含量,减轻肾组织的病理变化.结论:金樱子醇提物能减轻被动型Heymann肾炎模型大鼠肾小球病变并改善肾功能.
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| 关 键 词： | 金樱子醇提物 被动型Heymann肾炎 药理作用 |
| 修稿时间： | 2004-12-13 |
Effect of Jinyingzi on Experimental Passive-Heymann Nephritis in Rats |
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| Chen Jingmin,Li Youdi. Effect of Jinyingzi on Experimental Passive-Heymann Nephritis in Rats[J]. Journal of Chinese medicinal materials, 2005, 28(5): 408-410 |
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| Authors: | Chen Jingmin Li Youdi |
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| Affiliation: | Guangxi Instiute of Traditional Medical and Pharmaceutical Sciences, Nanning 530022. |
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| Abstract: | Objective: To study the pharmacological actions of Jinyingzi on experimental Passive-Heymann Nephritis (PHN) model rats. Methods: The rat model of PHN was induced by injecting anti-rabbit serum through caudal vein. The renal function about urinary protein, serum total protein, creatinine and urinary nitrogen on PHN rat were studied through op. Jinyingzi for 4 wk. Results: Jinyingzi can remarkably reduce urinary protein, serum levels of serum creatinine and serum urinary nitrogen, increase serum total protein content, alleviate the pathological injury in PHN rats. Conslusion: Jinyingzi can lessen pathological changes of glomerulus in PHN rats, ameliorate their renal function. |
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| Keywords: | Jinyingzi Passive-Heymann Nephritis model Pharmacoligical actions |
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