| 应用均匀设计法对灯盏花素纳米脂质体的处方优化 |
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| 引用本文： | 田维维,刘清飞,罗国安,王义明.应用均匀设计法对灯盏花素纳米脂质体的处方优化[J].中成药,2005,27(12):1373-1375. |
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| 作者姓名： | 田维维 刘清飞 罗国安 王义明 |
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| 作者单位： | 清华大学药物研究所,北京,100084 |
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| 摘 要： | 目的:对灯盏花素纳米脂质体的制备处方进行优化.方法:采用薄膜挤压法制备灯盏花素纳米脂质体,按均匀设计法,以包封率和载药量为考察指标,对实验结果进行最优子集法的二次回归优选处方配比.结果:用胆固醇和卵磷脂来包封的灯盏花素脂质体包封率为69.60%,载药量为29.06%,平均粒径为105.6 nm.结论:用均匀设计优化后的制备处方制得的灯盏花素脂质体,有较高的包封率和载药量.
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| 关 键 词： | 均匀设计 灯盏花素 纳米脂质体 处方优化 |
| 文章编号： | 1001-1528（2005）12-1373-03 |
| 收稿时间： | 01 11 2005 12:00AM |
| 修稿时间： | 2005-01-11 |
Application of uniform design for preparation of Breviscapine Liposomes |
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| TIAN Wei-wei,LIU Qing-fei,LUO Guo-an,WANG Yi-ming.Application of uniform design for preparation of Breviscapine Liposomes[J].Chinese Traditional Patent Medicine,2005,27(12):1373-1375. |
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| Authors: | TIAN Wei-wei LIU Qing-fei LUO Guo-an WANG Yi-ming |
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| Institution: | Institute of Material Medica, Tsinghua University, Beijing 100084, China |
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| Abstract: | AIM: To optimize the formulation in the preparation of the Breviscapine Liposomes. METHODS: Using film evaporation-extrusion method to prepare Breviscapine Liposomes according to the uniform design,a optimum formulation was established by determining the entrapment efficiency and the ratio of loading drug. RESULTS: The entrapment efficiency and the ratio of loading drug of Breviscapine Liposomes prepared with cholesterol and lecithin were determined to be 69.60% and 29.06%,respectively.The average diameter is 105.6 nm. CONCLUSION: The application of the uniform design is useful to achieve a large entrapment efficiency and ratio of loading drug. |
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| Keywords: | uniform design breviscapine liposomes optimum preparation |
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