变应性鼻炎患者血清中胸腺调节趋化因子及嗜酸性粒细胞趋化因子-2表达与临床意义

目的探讨胸腺调节趋化因子（thymus andactivation regulated chemokine,TARC）及嗜酸性粒细胞趋化因子-2（Eotaxin-2）在变应性鼻炎（AR）患者血清中的表达水平及其在AR发病机制中的作用及临床意义。方法应用酶联免疫吸附实验法检测64例AR患者和16例非变应性鼻炎（non-allergic rhinitis,NAR）患者外周血中TARC及Eotaxin-2水平。结果①AR患者血清中TARC及Eotaxin-2光密度（optical density,OD）均值分别为0.476±0.038、2.661±0.902,与NAR组比较OD均值为0.425±0.030、1.055±0.33,差异有统计学意义（t=5.309、2.731,P〈0.05）。②轻度持续性AR患者与中重度持续性AR患者血清中TARC OD均值分别为0.450±0.035、0.490±0.015,两组比较,差异无统计学意义（t=1.500,P=0.011）,而与NAR组比较,差异有统计学意义（t=2.100、3.080,P=0.010）。③轻度持续性AR患者与中重度持续性AR患者血清中Eotaxin-2 OD均值分别为2.660±0.900、3.13±1.375,两组比较,差异无统计学意义（t=1.618,P=0.032）,而与NAR组比较,差异有统计学意义（t=6.874、5.900,P=0.034）。④AR患者血清中TARC与Eotaxin-2表达呈明显正相关（r=0.880,P〈0.01）。结论 TARC及Eotaxin-2在轻度持续性AR及中重度持续性AR患者血清中明显升高,二者呈正相关,可能因TH2反应导致AR的发生,但其增高水平与临床症状严重程度无明显相关性。

Meta analysis of relationship between survivin and nasopharyngeal carcinoma

OBJECTIVE To evaluate the expression and significance of survivin in Nasopharyngeal Carcinoma(NPC).METHODS With comprehensive retrieval of related literature that had been published in China from academic journals collected in CBMdisc and other document database,there were 10 articles about casecontrol study(immunohistochemistry)and 3 articles on case-control study(RT-PCR),which were selected into system to be evaluated.Meta-analysis software RevMan4.2 was used to analyze the raw data and to calculate the value of combined odd ratio(OR)and 95% confidence interval(CI).RESULTS According to meta-analysis,in the combined articles which used immunohistochemistry method,the OR was 20.68 and the 95% CI was 13.87～30.84;and in the combined articles which used RT-PCR method,the OR was 17.09 while the 95% CI was 6.22～46.99.CONCLUSION The high expression of survivin may play an important role in progression and prognosis of nasopharyngeal carcinoma.