Posttonsillectomy vomiting. Ondansetron or metoclopramide during paediatric tonsillectomy: are two doses better than one? |
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Authors: | JOHN B ROSE MD THALIA M MARTIN MD |
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Institution: | *Department of Pediatric Anesthesiology, Alfred I. duPont Institute, Wilmington, Delaware and Department of Anesthesiology, Thomas Jefferson Medical College, Philadelphia, Pennsylvania, USA |
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Abstract: | This randomized, double blinded, placebo controlled, prospective study compared the antiemetic efficacy of one preoperative dose of metoclopramide 0.25 mg·kg?1 intravenously or ondansetron 0.15 mg·kg?1 intravenously with two doses of the same drugs (second dose administered one h postoperatively) in 200 preadolescent children undergoing tonsillectomy with either isoflurane or propofol anaesthesia. The incidence of posttonsillectomy vomiting was significantly reduced (P < 0.005) by two doses of either metoclopramide or ondansetron (18% and 8%, respectively) compared with placebo (50%). No difference in posttonsillectomy vomiting exists between the children who received isoflurane and those who received a propofol infusion. Our results suggest that two doses of metoclopramide 0.25 mg·kg?1 intravenously, like two doses of ondansetron 0.15 mg·kg?1, are effective in reducing vomiting after tonsillectomy in children who have received either isoflurane or propofol anaesthesia. |
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Keywords: | anaesthesia: outpatient anti-emetics: metoclopramide ondansetron complications: vomiting surgery: tonsillectomy |
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