Dementia in Swedish Twins: Predicting Incident Cases |
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Authors: | Margaret Gatz Chandra A Reynolds Deborah Finkel Nancy L Pedersen Ellen Walters |
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Institution: | (1) Department of Psychology, University of Southern California, 3620 S. McClintock Avenue, Los Angeles, 90089-1061, CA, USA;(2) Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden;(3) Department of Psychology, University of California-Riverside, Riverside, CA, USA;(4) Department of Psychology, Indiana University Southeast, New Albany, IN, USA |
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Abstract: | Thirty same-sex twin pairs were identified in which both members were assessed at baseline and one twin subsequently developed
dementia, at least 3 years subsequent to the baseline measurement, while the partner remained cognitively intact for at least
three additional years. Eighteen of the 30 cases were diagnosed with Alzheimer’s disease. Baseline assessments, conducted
when twins’ average age was 70.6 (SD = 6.8), included a mailed questionnaire and in-person testing. Which twin would develop
dementia was predicted by less favorable lipid values (higher apoB, ratio of apoB to apoA1, and total cholesterol), poorer
grip strength, and—to a lesser extent—higher emotionality on the EAS Temperament Scale. Given the long preclinical period
that characterizes Alzheimer’s disease, these findings may suggest late life risk factors for dementia, or may reflect changes
that are part of preclinical disease. |
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Keywords: | |
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