女性泌尿生殖道支原体检测及药敏分析

目的：了解女性患者泌尿生殖道支原体感染情况及检出的支原体对抗生素的敏感性及支原体耐药谱变化趋势，为临床用药提供依据。方法：收集2011年12月至2012年4月营口市中心医院门诊女性泌尿生殖道分泌物标本579例，检测解脲脲原体（Ureaplasma urealyticum，Uu）和人型支原体（Mycoplasma hominis，Mh）对10种临床常用抗生素敏感性，并对结果进行统计学分析。结果：（1）579例患者共检出支原体阳性263例，阳性率45．42％（263／579），其中Uu感染185例，占70．34％（185／263）；Mh感染15例，占5．70％（15／263）；Uu＋Mh混合感染63例，占23．95％（63／263）；（2）Uu对交沙霉素、强力霉素、美满霉素敏感，而对环丙沙星耐药；Mh对交沙霉素、强力霉素、美满霉素敏感，而对罗红霉素、阿奇霉素等耐药；Uu＋Mh对交沙霉素、强力霉素敏感，而对罗红霉素、阿奇霉素、环丙沙星耐药。结论：支原体是导致女性泌尿生殖道感染的常见病原体之一；支原体感染以Uu为主，其次为Uu＋Mh，Mh；单纯Uu、Mh及Uu合并Mh感染的药物敏感率和耐药率存在一定差异。

Mycoplasma Detection and Drug Sensitivity Analysis of Female Urogenital Tract

Objective： To know about the situation of mycoplasma infection distribution in female urogenital tract and its sensitivities to antimicrobials of OPD （ out-patient clinic ） patients. To provide the basis for the clinical medication. Methods： The vaginal secretion specimens from 579 female patients of Yingkou Central Hospital clinic from Dec 2011 to Apr 2012 were coleected. Uu （ Ureaplasma urealyticum） and Mh （Mycoplasma hominis） sensitivity to 10 kinds of clinical antibiotics, and the results were analyzed with statistical methods. Results： 263 patients were found in Mycoplasma positive among 579 patients, the positive rate was 45.42% （263/579）. Uu infection was 185 cases, the positive rate was 70. 34% （185/263）. Mh infection was 15 cases, the pos- itive rate was 5.70% （15/263）. The mixed infection was 63 cases, the positive rate was 23.95% （63/263）. Uu was sensitive to josamycin, minocycline, doxycycline and resistant to ciprofloxacin. Mh was sensitive to josamycin, minocycline, doxycycline and resistant to azithromycin and roxithromycin. The mixed infection of Uu and Mh was sensitive to josamycin, doxycycline and resistant to roxithromycin, azithromycin. Conclusions： Mycoplasma is a leading cause of urogenital tract infection in hospital. Uu infection is the major reason in hospital. The antibiotics sensitive rate and resistant rate of pure Uu, Mh and the mixed infection of Uu and Mh is different.