Frontal Atrophy and Attention Deficits in Older Adults with a History of Elevated Depressive Symptoms |
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| Authors: | Vonetta M Dotson Alan B Zonderman Christos Davatzikos Michael A Kraut Susan M Resnick |
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| Institution: | (1) Department of Clinical and Health Psychology, University of Florida, P.O. Box 100165, Gainesville, FL 32610-0165, USA;(2) Laboratory of Personality and Cognition, Intramural Research Program, National Institute on Aging, National Institutes of Health, NIH Biomedical Research Center, 251 Bayview Boulevard, Suite 100, Room #4B316, Baltimore, MD 21224, USA;(3) Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA;(4) Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, MD, USA;(5) Present address: Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA |
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| Abstract: | Studies of older adults with depressive disorders indicate greater cognitive deficits and brain alterations than would be
expected for their age. There is some evidence that these findings are present after a single episode of depression, but this
work has been cross-sectional in nature. We investigated both cross-sectional and longitudinal associations between a history
of elevated depressive symptoms (HDS), frontal lobe volumes, and cognitive performance within the context of normal age-related
changes over time in the Baltimore Longitudinal Study of Aging. After controlling for age, HDS was associated with smaller
total frontal gray matter volumes and with smaller regional volumes in the cingulate gyrus and orbitofrontal cortex. Men,
but not women, with HDS showed deficits in auditory attention span at older ages. Results confirm previous reports that even
a single episode of depression is associated with adverse outcomes in older adults but suggest that HDS does not affect longitudinal
trajectories of cognitive and brain volume change. |
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