改良小柴胡汤对慢性肝病患者肝纤维化标志物的作用

应用改良小柴胡汤制剂对８１例慢性肝病患者进行治疗学研究．旨在观察其对血清肝纤维化标志物的影响。结果显示改良小柴胡汤治疗可使血清透明质酸（ＨＡ）和Ⅲ型前胶原肽（ＰⅢＰ）由治疗前的２４５．８９±１４８．４９ ｎｇ／ｍｌ和２６１．８９±１３４．４２μｇ／Ｌ分别降至１２５．４３±８５．４６ ｎｇ／ｍｌ和１４４ ０４±８３．９９μｇ／Ｌ（Ｐ＝０．０００），均优于对照组；治疗组的ＨＡ和ＰⅢＰ复常率分别为３４．３８％（２２／６４ ）和５０．６８％（３７／７３）。提示改良小柴胡汤制剂对肝纤维化过程具有一定的抑制作用，长期应用将有助于延缓肝炎肝硬变的发生。

The effects of Xiaochaihu Tang on markers of hepatic fibrogenesis in patients with chronic liver disease

In order to evaluate the effects of Xiaochaihu Tang (Minor Decoction of Bupleurum ) on serum markers of hepatic fibrogenesis,a controlled clinical trial was conducted in 81 patients with chronic viral hepatitis and liver cirrhosis. Hyaluronate (HA ) and procollagen peptide (P P )were tested before during and after treatment. Before treatment. the average values of HA and P P were 245. 89 148. 49 ng/ml and 261. 89 134. 42 g/L respectively ; and afer treatment decreased to 125. 43=85. 46 ng,/ml and 144. 04 83. 99 g/L (P = 0. 000 ), respectively. At the time stopping the treatment. HA and P P were normal in 34. 38 % (22/64 ) and 50. 68 % (37/73 ) of the Xiaochaihu tang treated patients. respectively. The results indicate that treatment of Xiaochaihu Tang is helpful to slow down the development of hepatic fibrogenesis in patients with chronic hepatitis and liver cirrhosis.