| 改良小柴胡汤对慢性肝病患者肝纤维化标志物的作用 |
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| 引用本文： | 邓子德,肖杰生,俞洪林.改良小柴胡汤对慢性肝病患者肝纤维化标志物的作用[J].中国中西医结合消化杂志,1996(4). |
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| 作者姓名： | 邓子德 肖杰生 俞洪林 |
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| 作者单位： | 中山医科大学附属第三医院!广州510630 |
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| 摘 要： | 应用改良小柴胡汤制剂对８１例慢性肝病患者进行治疗学研究．旨在观察其对血清肝纤维化标志物的影响。结果显示改良小柴胡汤治疗可使血清透明质酸（ＨＡ）和Ⅲ型前胶原肽（ＰⅢＰ）由治疗前的２４５．８９±１４８．４９ ｎｇ／ｍｌ和２６１．８９±１３４．４２μｇ／Ｌ分别降至１２５．４３±８５．４６ ｎｇ／ｍｌ和１４４ ０４±８３．９９μｇ／Ｌ（Ｐ＝０．０００），均优于对照组；治疗组的ＨＡ和ＰⅢＰ复常率分别为３４．３８％（２２／６４ ）和５０．６８％（３７／７３）。提示改良小柴胡汤制剂对肝纤维化过程具有一定的抑制作用，长期应用将有助于延缓肝炎肝硬变的发生。
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| 关 键 词： | 慢性肝病 肝纤维化 小柴胡汤 透明质酸 前胶原肽 |
The effects of Xiaochaihu Tang on markers of hepatic fibrogenesis in patients with chronic liver disease |
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| Deng Zide,Xiao Jiesheng,Yu Honglin.The effects of Xiaochaihu Tang on markers of hepatic fibrogenesis in patients with chronic liver disease[J].Chinese Journal of Integrated Traditional and Western Medicine on Digestion,1996(4). |
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| Authors: | Deng Zide Xiao Jiesheng Yu Honglin |
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| Institution: | The 3rd Affiliated Hospital. Sun Yat--Sen University of Medical Science .Guangzhou. 510630 |
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| Abstract: | In order to evaluate the effects of Xiaochaihu Tang (Minor Decoction of Bupleurum ) on serum markers of hepatic fibrogenesis,a controlled clinical trial was conducted in 81 patients with chronic viral hepatitis and liver cirrhosis. Hyaluronate (HA ) and procollagen peptide (P P )were tested before during and after treatment. Before treatment. the average values of HA and P P were 245. 89 148. 49 ng/ml and 261. 89 134. 42 g/L respectively ; and afer treatment decreased to 125. 43=85. 46 ng,/ml and 144. 04 83. 99 g/L (P = 0. 000 ), respectively. At the time stopping the treatment. HA and P P were normal in 34. 38 % (22/64 ) and 50. 68 % (37/73 ) of the Xiaochaihu tang treated patients. respectively. The results indicate that treatment of Xiaochaihu Tang is helpful to slow down the development of hepatic fibrogenesis in patients with chronic hepatitis and liver cirrhosis. |
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| Keywords: | Chronic liver disease Fibrogenesis Xiaochaihu Tang Hyaluronate Procollagen peptide |
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